an array of rolled up nanomembranes


Biomedical applications


	Real-time tracking of microrobots in 3D in deep tissue

14 Aug 2019

Real-time tracking of microrobots in 3D in deep tissue

Opto-acoustic imaging is used to track microtubular robots in three dimensions, in real-time, in deep phantom and ex-vivo tissue.

Nano Lett. 19, 6612 (2019)

Press Release

15 Jan 2018

Spermbot video now among Top 5 ever

The Spermbot video has now become the 5th most viewed video of the American Chemical Society. Click on the following link to watch it.

YouTube Video

20 Dez 2017

American Chemical Society highlights our work as Top News

Original work:

ACS Nano 12, 327 (2018)

ACS Top News

4 Dec 2017

Chemotherapeutic micromotor for targeted drug delivery

A sperm-driven micromotor acts as a targeted drug delivery system to potentially treat diseases in the female reproductive tract. 

ACS Nano 12, 327 (2018)

24 May 2017

Opportunities and challenges of medical microbots

In this extended comment we call on microrobotics researchers, materials scientists, bioimaging and medical specialists to work together to tackle the challenges on the way to in-vivo applications.

Nature 545, 406 (2017)

21 Mar 2017

Spermatozoa as robotic microswimmers

V. Magdanz, M. Medina-Sánchez, L. Schwarz, H. Xu, J. Elgeti, O. G. Schmidt

Adv. Mater. 29, 1606301 (2017)

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24 Jan 2017

Monolithically integrated microtube cavities for optofluidic sensing

Monolithically integrated vertical ring resonators pave the way for optofluidics in three-dimensions on photonic chips.

Opt. Lett. 42, 486 (2017)

6 Jun 2016

High-performance DNA biosensor

Microtubular sensor reaches attomolar level detection of Avian Influenza Virus H1N1 DNA without any labelling or amplification. 

Nano Lett. 16, 4288 (2016)

6 Jun 2016

Human cancer cell mitosis in transparent microtubes

Tumor cell devision is mimicked inside blood capillaries by investigating single-cell mitosis of living human cancer cells trapped inside rolled-up microtubes. 

ACS Nano 10, 5835 (2016)

13 Jan 2016

American Chemical Society highlights our work as Top News

Original work:

Nano Lett. 16, 555 (2016)

ACS Top News

21 Dec 2015

Micromotorized sperms for artificial fertilization

Magnetically activated microhelices serve as motors for transporting sperm cells with motion deficiencies to help them carry out their natural function. 

Nano Lett. 16, 555 (2016)

30 Nov 2015

Biogenic microdaggers for single-cell surgery and drug release

S. K. Srivastava, M. Medina-Sánchez, B. Koch, O. G. Schmidt

Adv. Mater. 28, 832 (2016)

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	Biomimetic microelectronics for regenerative neuronal cuff implants

Biomimetic microelectronics for regenerative neuronal cuff implants

D. Karnaushenko, N. Münzenrieder, D. D. Karnaushenko, B. Koch, A. K. Meyer, S. Baunack, L. Petti, G. Tröster, D. Makarov, O. G. Schmidt

 Adv. Mater. 27, 6797 (2015)

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	Neural stem cell migration under spatial confinement

Neural stem cell migration under spatial confinement

We exploit the well-defined geometry and optical transparency of glass microtubes to investigate how scaffold dimensionality and cell confinement influence the spontaneous migration of neural stem cells.

Nano Lett. 15, 5530 (2015)

	Ultra-compact helical antennas for smart system implants

Ultra-compact helical antennas for smart system implants

Ultra-compact helical antennas with a total length five times smaller compared to their conventional dipole counterparts are demonstrated to operate in the Industry-Scientific-Medical radio band. 

NPG Asia Mater. 7, e188 (2015)

	Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies

Rolled-up functionalized nanomembranes as three-dimensional cavities for single cell studies

We use micropatterning and strain engineering to encapsulate single living mammalian cells into transparent tubular architectures consisting of 3D rolled-up nanomembranes.

Nano Lett., 14, 4197 (2014)

Cover Pages

	Impedemetric sensing of ionic fluids and single cells in a single microtube

Impedemetric sensing of ionic fluids and single cells in a single microtube

Ultracompact three-dimensional tubular structures integrating Au-based electrodes serve as impedimetric microsensors for the in-flow determination of mono- and divalent ionic species and HeLa cells. 

Nano Lett. 14, 2219 (2014)

	A sperm driven micro-bio-robot

A sperm driven micro-bio-robot

V. Magdanz, S. Sanchez, O. G. Schmidt

Adv. Mater. 25, 6581 (2013)

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	Chemotactic behaviour of artificial engines

Chemotactic behaviour of artificial engines

Dr. L. Baraban, Dr. S. M. Harazim, Dr. S. Sanchez, Prof. Dr. O. G. Schmidt

Angew. Chem. Int. Edit. 52, 5552 (2013)

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	Self-propelled nanotools drilling into cells

Self-propelled nanotools drilling into cells

We design nanoscale tools in the form of autonomous and remotely guided catalytically self-propelled rolled-up tubes.

ACS Nano 6, 1751 (2012)

	On-chip integration of rolled-up ring resonators as label-free optofluidic sensors

On-chip integration of rolled-up ring resonators as label-free optofluidic sensors

The advances we have made in engineering of tubular optical sensors and their on-chip integration allows us to fabricate rolled-up optofluidic ring resonators based on glass material with high quality factors fully integrated on-chip. 

Lab Chip 12, 2649 (2012)

	Lab-in-a-tube

Lab-in-a-tube

A lab-in-a-tube device comprises numerous ultracompact components in a single tube which can be developed using rolled-up technology.

Lab Chip 12, 1917 (2012)

	Lab-in-a-tube

Lab-in-a-tube for single cell optofluidic detection

E. J. Smith, S. Schulze, S. Kiravittaya, Y. Mei, S. Sanchez, O. G. Schmidt

Nano Lett. 11, 4037 (2011)

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	Towards remotely controlled intelligent microrobots

Towards remotely controlled intelligent microrobots

In this tutorial review we describe recent progress on catalytic microtubular engines fabricated by rolled-up nanotech.

Chem. Soc. Rev. 40, 2109 (2011)

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	Guinness World Record® for "Smallest Man-Made Jet Engine"

Guinness World Record® for "Smallest Man-Made Jet Engine"

"The smallest man-made jet engine measures just 600nm across and weighs 1 picogram.

Die Welt (March 8, 2011)

	Microbots swimming in the flowing streams of microfluidic channels

Microbots swimming in the flowing streams of microfluidic channels

The motion of artificial catalytic nanomachines is commonly studied in free bulk solution, which differs significantly from the stream-like channel networks existing in the human body. 

J. Am. Chem. Soc. 133, 701 (2011)

	Transport of animal cell material by catalytic microbots

Transport of animal cell material by catalytic microbots

Animal cells can be transported within a fluid in a controllable manner by using artificial microbots.

Chem. Commun. 47, 698-700 (2011)

	Tubular optofluidic sensors for enhanced refractive index sensing

Tubular optofluidic sensors for enhanced refractive index sensing

Optofluidic microcavities from rolled-up ring resonators with subwavelength wall thicknesses are fabricated with excellent sensing function.

ACS Nano 4, 3123 (2010)

	Neuron cells cultured in rolled-up microtubes

Neuron cells cultured in rolled-up microtubes

Primary mouse motor neurons and immortalised CAD cells, a cell line derived from the central nervous system, can be well cultured on arrays of rolled-up microtubes.

Adv. Eng. Mater. 12, B558 (2010)

	Collective behaviour of artifcial autonomous systems

Collective behaviour of artifcial autonomous systems

Artificial autonomous systems act as catalytic water striders at the air–liquid interface of hydrogen peroxide solution.

Adv. Mater. 22, 4340 (2010)

	Highly efficient locomotion of hybrid biocatalytic microengines

Highly efficient locomotion of hybrid biocatalytic microengines

We have designed a novel hybrid biocatalytic microengine.

J. Am. Chem. Soc. 132, 13144 (2010)

	Magnetic control of tubular catalytic microbots

Magnetic control of tubular catalytic microbots

A. A. Solovev, S. Sanchez, M. Pumera, Y. F. Mei, O. G. Schmidt

Adv. Funct. Mater. 20, 2430 (2010)

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	 Cell culturing in single tubes integrated on a Si Chip

Cell culturing in single tubes integrated on a Si Chip

Detailed investigations of individual yeast cells in a single transparent microtube reveal the mechanical interaction between the tube and the 2D confined cells causing different cellular assemblies. 

Lab Chip 9, 263-268 (2009)

	Microtubular jet engines

Microtubular jet engines

A. A. Solovev, Y. Mei, E. B. Ureña, G. Huang, O. G. Schmidt

Small 5, 1688 (2009)

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	Ferngesteuerte Mikroraketen

Ferngesteuerte Mikroraketen

Wir haben winzige Mikroraketen hergestellt, die sich durch ein Magnetfeld fernsteuern lassen.

Spektrum der Wissenschaft, S.16, Juli 2009

Welt der Physik 16.05.2009

	Strain engineered micro-/nanotubes on polymers

Strain engineered micro-/nanotubes on polymers

Y. Mei, G. Huang, A. A. Solovev, E. Bermúdez Ureña, I. Mönch, F. Ding, T. Reindl, R. K. Y. Fu, P. K. Chu, O. G. Schmidt

Adv. Mater. 20, 4085 (2008)

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	Glucose detection on the femtoliter scale

Glucose detection on the femtoliter scale

We use Si/SiO microtubes as optofluidic components to sense glucose concentrations in water. 

Appl. Phys. Lett. 93, 094106 (2008)