Surface modification of Ti-Nb alloys for biomedical use

(Oberflächenmodifikation von Ti-Nb Legierungen für biomedizinische Anwendungen)

A decisive aspect for long-term implantation is the creation of materials surface states with suitable topography, roughness, composition, surface energy etc. that enable optimum bone tissue ingrowth. The extremely high corrosion resistance of Ti-Nb alloys restricts surface treatments, e.g. chemical etching, which are established for conventional implant materials. We develop strategies for nano- and micro-structuring of beta-type alloy surfaces by (electro-)chemical means. Nanoroughening of Ti-Nb surfaces by treatment in oxidative acid solution was found to support the apatite-forming ability and to stimulate the response of human mesenchymal stromal cells (hMSC). Anodization treatments under defined conditions yield oxide nanotubes, microporous oxide coatings or compact oxide films whereby the high Nb content of the alloys has significant impact on the growth processes.
In a cooperative work the concept of nanopatterning using noble metal nanoparticles to stimulate cell biological functionality was successfully transferred to the metal surfaces.  

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R. Medda, A. Helth, Investigation of early cell-surface interactions of human mesenchymal stem cells on nanopatterned β-type titanium-niobium alloy surfaces,
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P.F. Gostin at al., Surface treatment, corrosion behaviour and apatite-forming ability of Ti-45Nb implant alloy,
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